Biofabricated Human Tissue models - Biodimension

BioDimension’s BioDEpi models consist of, epidermal keratinocytes isolated from human culture on a transwell to form a multilayered, highly differentiated model of the human epidermis. The cells were cultured using in-house proprietary serum-free media composition to attain a high level of differentiation using in vitro cell culture techniques. It can be used as a model system to study the effects of various agents, such as cosmetics, drugs, and chemicals, on human skin. It can also be used to test the safety and efficacy of various skin care products and therapies intended to treat skin conditions, such as psoriasis, eczema, and skin cancer.

BioDFT is a lab-grown tissue that mimics the structure and function of the entire thickness of human skin, including both the epidermis and dermis layers. In the pharmaceutical industry, reconstructed full-thickness skin can be used to test the efficacy and safety of new drugs and therapies. In the cosmetics industry, it can be used to test the safety and efficacy of new skin care products. In the medical device industry, it can be used to test the compatibility and safety of medical implants and devices.

BioDCore is a reconstructed epithelial layer of cornea resembles the natural corneal epithelium, which can be used as a model system to study the effects of various agents, such as drugs, contact lenses, and environmental toxins, on the corneal epithelium. It can also be used to test the safety and efficacy of various ophthalmic therapies and treatments, such as corneal wound healing, drug delivery, and tissue regeneration.

BioDNasal mimics the structure and function of the natural epithelium lining of the nasal cavity. The reconstructed nasal epithelium can be used as a model system to study the effects of environmental pollutants, allergens, and other toxicants on the respiratory system. It can also be used to test the safety and efficacy of drugs and other therapies intended to treat respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis.

BioDGine is the lab-grown gingival tissue that mimics the structure and function of the outermost layer of the gums or gingiva. It can be used as a model system to study the effects of various agents, such as dental materials, oral care products, and bacteria, on the gingival epithelium. It can also be used to test the safety and efficacy of various dental therapies and treatments, such as periodontal disease treatments, implants, and orthodontic devices.

BioDAir is the lab made tissue that mimics the structure and function of the mucociliary epithelium, which lines the respiratory tract and helps to protect the lungs from harmful particles and microorganisms. This can be used as a model system to study the effects of various agents, such as air pollutants, allergens, and viruses, on the respiratory epithelium. It can also be used to test the safety and efficacy of various respiratory therapies and treatments, such as inhalation drugs and vaccines.

BioDAirFT is the mucociliary epithelium with stroma, this is an important tool for researchers and clinicians studying the structure and function of the respiratory tract and developing new treatments for respiratory diseases. It allows for the testing of new products and treatments without the use of animals and provides a more accurate representation of human respiratory tissue than traditional cell culture methods.

BioDHeart is the reconstructed heart tissue with the similar function to study the effects of various agents, such as drugs, toxins, and diseases, on the heart tissue. It can also be used to test the safety and efficacy of various drugs, cardiovascular therapies and treatments, such as cardiac pacemakers, heart valves, and stents.

BioDLive is the reconstructed liver tissue with the similar function to of native human tissue made with hepatocytes to study the liver function and metabolism. It can also be used to can be used to test the efficacy and safety of new drugs and therapies

BioDIntEp is a reconstructed epithelial layer that lines the intestinal wall, which can be used to test the safety and efficacy of various therapies and treatments intended to treat intestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer. Also, to study the interactions between the intestinal epithelium and the gut microbiota.

BioDIntFT is a reconstructed epithelial layer with finger-like protrusions called villi, can be used as a model system to study the effects of various agents, such as drugs, dietary components, and microorganisms, on the intestinal epithelium. It can also be used to test the safety and efficacy of various therapies and treatments for intestinal diseases.

BioDUro is a reconstructed epithelial layer of the urinary bladder, Which plays a critical role in protecting the bladder from the toxic effects of urine.This helps to study the effects of various agents, such as drugs, toxins, and pathogens, on the bladder epithelium. It can also be used to test the safety and efficacy of various bladder therapies and treatments, such as drugs for bladder cancer or interstitial cystitis, or medical devices such as urinary catheters.

BioDVag is a functional replica of human vaginal epithelium, The reconstructed vaginal epithelium can be used as a model system to study the effects of various agents, such as contraceptives, lubricants, and infectious agents, on the vaginal epithelium. It can also be used to test the safety and efficacy of various vaginal therapies and treatments, such as creams and suppositories used to treat vaginal infections and hormone replacement therapies used to alleviate menopausal symptoms.